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Safety |
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| There are currently no reported safety issues
or contraindications with NKCP Nattokinase. Being
an extract from a traditional food, this product
is very safe to take. We do advise, however, that if you have
a specific medical problem or if you are taking
prescription medications (especially medication relating to thrombosis
or blood circulation), you consult your doctor before
taking NKCP nattokinase. Over 14 safety studies have been
carried out with NKCP, all of which show absolutely
no safety problems or toxicity. Eight of these studies are
summarized below: |
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| 1. |
Mutagenicity |
Negative |
| 2. |
Acute toxicity (rat) |
LD50 > 5,000 mg/kg |
| 3. |
Subacute toxicity (rat) |
Non-toxic-effect dose > 1,325 mg/kg body
weight/day male
Non-toxic-effect dose > 1,541 mg/kg body weight/day female |
| 4. |
Antigenicity (guinea pig) |
None (subcutaneous, intravenous) |
| 5. |
Excess intake (rat) |
Rat models of prolonged coagulation given five times the
normal dose through the duodenum showed no bleeding, and
NKCP induced no remarkable symptoms in the coagulation system. |
| 6. |
Prolongation of bleeding time (rat) |
An oral dose of a maximum 300 mg/kg body weight had no
effect on the prolongation of the bleeding time. |
| 7. |
Long-term intake in humans: |
Eight healthy adults were given 750 mg of NKCP daily for
6 weeks and no clinical adverse effects were observed. |
| 8. |
Excess intake in humans |
23 healthy adults were given 1,250 mg of NKCP daily for
7 days and no clinical adverse effects were observed. |
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